Publications

52.   Wang, Z. H.; Li, F.; Zhao, L.; He, Q. Q.; Chen, F. E.; Zheng, C., An efficient enantioselective synthesis of florfenicol via asymmetric aziridination. Tetrahedron 2011, 67 (47), 9199-9203.

51.   Ma, X. D.; Zhang, X.; Yang, S. Q.; Dai, H. F.; Yang, L. M.; Gu, S. X.; Zheng, Y. T.; He, Q. Q.; Chen, F. E., Synthesis and biological evaluation of (+/-)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry 2011, 19 (16), 4704-4709.

50.   Ma, X. D.; Zhang, X.; Dai, H. F.; Yang, S. Q.; Yang, L. M.; Gu, S. X.; Zheng, Y. T.; He, Q. Q.; Chen, F. E., Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry 2011, 19 (15), 4601-4607.

49.   Li, F.; Wang, Z. H.; Zhao, L.; Xiong, F. J.; He, Q. Q.; Chen, F. E., An efficient enantioselective synthesis of florfenicol via a vanadium-catalyzed asymmetric epoxidation. Tetrahedron-Asymmetry 2011, 22 (12), 1337-1341.

48.   Li, F.; Wang, Z. H.; Zhao, L.; Chen, F. E., A Facile and Efficient Asymmetric Synthesis of Florfenicol. Synlett 2011,  (19), 2883-2885.

47.   Huang, J. P.; Zhao, L.; Gu, S. X.; Wang, Z. H.; Zhang, H.; Chen, F. E.; Dai, H. F., Efficient Asymmetric Synthesis of (2R,3R)-3-{(1R)-1- tert-Butyl(dimethyl)-siloxy ethyl}-4-oxoazetidin-2-yl Acetate. Synthesis 2011,  (4), 555-562.

46.   He, Q. Q.; Zhang, X.; Wu, H. Q.; Gu, S. X.; Ma, X. D.; Yang, L. M.; Zheng, Y. T.; Chen, F. E., Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry 2011, 19 (18), 5553-5558.

45.   He, Q. Q.; Gu, S. X.; Liu, J.; Wu, H. Q.; Zhang, X.; Yang, L. M.; Zheng, Y. T.; Chen, F. E., Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity. Bioorganic & Medicinal Chemistry 2011, 19 (16), 5039-5045.

44.   Gu, S. X.; Zhang, X.; He, Q. Q.; Yang, L. M.; Ma, X. D.; Zheng, Y. T.; Yang, S. Q.; Chen, F. E., Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry 2011, 19 (14), 4220-4226.

43. Gu, S. X.; Yang, S. Q.; He, Q. Q.; Ma, X. D.; Chen, F. E.; Dai, H. F.; De Clercq, E.; Balzarini, J.; Pannecouque, C., Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry 2011, 19 (23), 7093-7099.

42. Gu, S. X.; He, Q. Q.; Yang, S. Q.; Ma, X. D.; Chen, F. E.; De Clercq, E.; Balzarini, J.; Pannecouque, C., Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs. Bioorganic & Medicinal Chemistry 2011, 19 (17), 5117-5124.

41. Chen, X. X.; Xiong, F.; Fu, H.; Liu, Z. Q.; Chen, F. E., Synthetic Studies on (+)-Biotin, Part 15(1)): A Chiral Squaramide-Mediated Enantioselective Alcoholysis Approach toward the Total Synthesis of (+)-Biotin. Chemical & Pharmaceutical Bulletin 2011, 59 (4), 488-491.

40. Chen, W. X.; Zu, Y. K.; Huang, Q.; Chen, F. E.; Wang, G. F.; Lan, W. X.; Bai, C. X.; Lu, S. H.; Yue, Y.; Deng, F., Study on Metabonomic Characteristics of Human Lung Cancer Using High Resolution Magic-angle Spinning (1)H NMR Spectroscopy and Multivariate Data Analysis. Magnetic Resonance in Medicine 2011, 66 (6), 1531-1540.

39. Chen, W. X.; Lou, H. Y.; Zhang, H. P.; Nie, X.; Lan, W. X.; Yang, Y. X.; Xiang, Y.; Qi, J. P.; Lei, H.; Tang, H. R.; Chen, F. E.; Deng, F., Grade classification of neuroepithelial tumors using high-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy and pattern recognition. Science China-Life Sciences 2011, 54 (7), 606-616.

38. Zeng, Z. S.; Liang, Y. H.; Feng, X. Q.; Chen, F. E.; Pannecouque, C.; Balzarini, J.; De Clercq, E., Lead Optimization of Diarylpyrimidines as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. ChemMedChem 2010, 5 (6), 837-840.

37. Zeng, Z. S.; He, Q. Q.; Liang, Y. H.; Feng, X. Q.; Chen, F. E.; De Clercq, E.; Balzarini, J.; Pannecouque, C., Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy. Bioorganic & Medicinal Chemistry 2010, 18 (14), 5039-5047.

36. Xiong, F.; Chen, X. X.; Liu, Z. Q.; Chen, F. E., A novel synthetic strategy for the stereospecific total synthesis of (+/-)-biotin. Tetrahedron Letters 2010, 51 (28), 3670-3672.

35. Xiong, F.; Chen, X. X.; Chen, F. E., An improved asymmetric total synthesis of (+)-biotin via the enantioselective desymmetrization of a meso-cyclic anhydride mediated by cinchona alkaloid-based sulfonamide. Tetrahedron-Asymmetry 2010, 21 (6), 665-669.

34. Liang, Y. H.; He, Q. Q.; Zeng, Z. S.; Liu, Z. Q.; Feng, X. Q.; Chen, F. E.; Balzarini, J.; Pannecouque, C.; De Clercq, E., Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry 2010, 18 (13), 4601-4605.

33. Kuang, Y. Y.; Niu, J. Z.; Chen, F. E., Synthetic Studies on Camptothecins Part 3 Total Synthesis of (20S)-7-Ethyl-10-hydroxycamptothecin via a Bifunctional Thiourea-Based Cinchona Alkaloid-Mediated Enantioselective Cyanosilylation Strategy. Helvetica Chimica Acta 2010, 93 (10), 2094-2099.

32. Huang, J. P.; Chen, X. X.; Gu, S. X.; Zhao, L.; Chen, W. X.; Chen, F. E., An Efficient Method for Removal of Residual Palladium from Organic Solution of Faropenem Sodium in the Pd(II)-Catalyzed Cleavage of Allyl Faropenem. Organic Process Research & Development 2010, 14 (4), 939-941.

31. Feng, X. Q.; Zeng, Z. S.; Liang, Y. H.; Chen, F. E.; Pannecouque, C.; Balzarini, J.; De Clercq, E., Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV. Bioorganic & Medicinal Chemistry 2010, 18 (7), 2370-2374.

30. Dai, L.; Wang, S. X.; Chen, F. E., A Bifunctional Cinchona Alkaloid-Squaramide Catalyst for the Highly Enantioselective Conjugate Addition of Thiols to trans-Chalcones. Advanced Synthesis & Catalysis 2010, 352 (13), 2137-2141.

29. Chen, W. X.; Zhang, P.; Chen, F. E., NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose. Magnetic Resonance in Chemistry 2010, 48 (8), 651-655.

28. Xiong, Y. Z.; Chen, F. E.; Balzarini, J.; De Clercq, E.; Pannecouque, C., Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors Part 13. Synthesis of Fluorine-Containing Diaryltriazine Derivatives for in vitro Anti-HIV Evaluation against Wild-Type Strain. Chemistry & Biodiversity 2009, 6 (4), 561-568.

27. Xiong, X. D.; Chen, W. X.; Kuang, Y. Y.; Chen, F. E., A Novel and Practical Synthesis of 2-Amino-5-hydroxypropiophenone. Organic Preparations and Procedures International 2009, 41 (5), 423-427.

26. Wang, Y. P.; Chen, F. E.; De Clercq, E.; Balzarini, J.; Pannecouque, C., Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry 2009, 44 (3), 1016-1023.

25. Wang, S. X.; Chen, F. E., A Novel Cost-Effective Thiourea Bifunctional Organocatalyst for Highly Enantioselective Alcoholysis of meso-Cyclic Anhydrides: Enhanced Enantioselectivity by Configuration Inversion. Advanced Synthesis & Catalysis 2009, 351 (4), 547-552.

24. Liang, Y. H.; Feng, X. Q.; Zeng, Z. S.; Chen, F. E.; Balzarini, J.; Pannecouque, C.; De Clercq, E., Design, Synthesis, and SAR of Naphthyl-Substituted Diarylpyrimidines as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Chemmedchem 2009, 4 (9), 1537-1545.

23. Liang, Y. H.; Chen, F. E., QSAR studies for diarylpyrimidines against HIV-1 reverse transcriptase wild-type and mutant strains. European Journal of Medicinal Chemistry 2009, 44 (2), 625-631.

22. Kuang, Y. Y.; Chen, F. E., Copper- and Phosphine-Free Sonogashira Coupling Reaction Catalyzed by Polyurea-Encapsulated Palladium(II). Helvetica Chimica Acta 2009, 92 (5), 897-902.

21. Huang, J.; Xiong, F.; Wang, Z. H.; Chen, F. E., Unexpected Ring Expansion of the (3aS,6aR)-gamma-Thiolactone Moiety during the Introduction of the (+)-Biotin Side Chain. Helvetica Chimica Acta 2009, 92 (7), 1445-1449.

20. Feng, X. Q.; Liang, Y. H.; Zeng, Z. S.; Chen, F. E.; Balzarini, J.; Pannecouque, C.; De Clercq, E., Structural Modifications of DAPY Analogues with Potent Anti-HIV-1 Activity. Chemmedchem 2009, 4 (2), 219-224.

19. Zhang, L. P.; Bao, Y.; Knang, Y. Y.; Chen, F. E., Synthetic Studies on Camptothecins Part 1 An Improved Asymmetric Total Synthesis of (20S)-Camptothecin. Helvetica Chimica Acta 2008, 91 (11), 2057-2061.

18. Yu, X. J.; Zhang, H.; Xiong, F. J.; Chen, X. X.; Chen, F. E., An Improved Convergent Strategy for the Synthesis of Oligoprenols. Helvetica Chimica Acta 2008, 91 (10), 1967-1974.

17. Xiong, Y. Z.; Chen, F. E.; Balzarini, J.; De Clercq, E.; Pannecouque, C., Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: Structural modulations of diaryltriazines with potent anti-HIV activity. European Journal of Medicinal Chemistry 2008, 43 (6), 1230-1236.

16. Wang, Y. P.; Chen, F. E.; De Clercq, E.; Balzarini, J.; Pannecouque, C., Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio) pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry 2008, 16 (7), 3887-3894.

15. Wang, Y. P.; Chen, F. E.; Balzarini, J.; De Clercq, E.; Pannecouque, C., Non-nucleoside HIV-1 reverse-transcriptase inhibitors - Part 10 - Synthesis and anti-HIV activity of 5-Alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'Dihydro-Alkoxy-Benzyl-Oxopyrimidine' (DABO) analogues. Chemistry & Biodiversity 2008, 5 (1), 168-176.

14. Huang, J.; Xiong, F.; Chen, F. E., Total synthesis of (+)-biotin via a quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride strategy. Tetrahedron-Asymmetry 2008, 19 (12), 1436-1443.

13. Dai, H. F.; Chen, W. X.; Zhao, L.; Xiong, F.; Sheng, H.; Chen, F. E., Synthetic studies on (+)-biotin, Part 11: Application of Cinchona alkaloid-mediated asymmetric alcoholysis of meso-cyclic anhydride in the total synthesis of (+)-biotin. Advanced Synthesis & Catalysis 2008, 350 (10), 1635-1641.

12. Zhang, P.; Huang, J.; Chen, F. E., NMR studies of a series of shikimic acid derivatives. Journal of the Chinese Chemical Society 2007, 54 (5), 1313-1320.

11. Zhang, H.; Chen, F. E.; Chen, M. Q., (3S, 4S)-1-Benzhydryl-4- (R)-2,2-dimethyl-1,3-dioxolan-4-yl -3- (S)-1-hydroxy ethyl azetidin-2-one. Acta Crystallographica Section E-Structure Reports Online 2007, 63, O3099-U2542.

10. Yu, X. J.; Dai, H. F.; Chen, F. E., Synthetic studies on coenzyme Q(10) part 3 - An improved C-5+C-45 approach to the stereoselective synthesis of coenzyme Q(10) via metal-halogen exchange strategy. Helvetica Chimica Acta 2007, 90 (5), 967-971.

9. Wang, S. X.; Chen, F. E., Novel polymer-supported chiral catalysts for the asymmetric addition of diethylzinc to aldehydes. Chemical & Pharmaceutical Bulletin 2007, 55 (7), 1011-1013.

8. Liu, J.; Chen, F. E.; Chen, M. Q., (4R,5S)-methyl 1,3-dibenzyl-5- (R)-2-(hydroxydiphenylmethyl)pyrrolidine-1-carbonyl -2-o xoimidazolidine-4-carboxylate. Acta Crystallographica Section E-Structure Reports Online 2007, 63, O4127-U3773.

7. Kuang, Y. Y.; Chen, F. E., Synthesis and molecular structure of ethyl N-tosyl-(R)-prolyloxy -2(S)- 4-cyano-8,8-ethylenedioxy-5-oxo-5,6,7,8-te trahydroindolizin-3-yl Acetate, a key intermediate in the total synthesis of (20S)-camptothecins. Molecules 2007, 12 (11), 2507-2514.

6. Ji, L.; Chen, F. E.; Xie, B.; De Clercq, E.; Balzarini, J.; Pannecouque, C., Synthesis and anti-HIV activity evaluation of 1- alkenyl or alkynyl or alkyloxy)methyl -5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. European Journal of Medicinal Chemistry 2007, 42 (2), 198-204.

5. Ji, L.; Chen, F. E.; De Clercq, E.; Balzarini, J.; Pannecouque, C., Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Journal of Medicinal Chemistry 2007, 50 (8), 1778-1786.

4. Huang, J.; Chen, F. E., An efficient synthesis of a potential (-)-reserpine intermediate from (-)-shikimic acid of the chiral pool. Helvetica Chimica Acta 2007, 90 (7), 1366-1372.

3. Dai, L.; Chen, F. E.; Chen, M. Q., (5R,6R)-Methyl 6-methyl-2-phenyl-5,6dihydro-4H-1,3-oxazine-5-carboxylate. Acta Crystallographica Section E-Structure Reports Online 2007, 63, O2365-O2366.

2. Chen, F. E.; Zhao, J. F.; Xiong, F. J.; Xie, B.; Zhang, P., An improved synthesis of a key intermediate for (+)-biotin from D-mannose. Carbohydrate Research 2007, 342 (16), 2461-2464.

1. Chen, F. E.; Xie, B.; Zhang, P.; Zhao, J. F.; Wang, H.; Zhao, L., An efficient and green oxidation of vicinal diols to aldehydes using polymer-supported (diacetoxyiodo)benzene as the oxidant. Synlett 2007,  (4), 619-622.